Table 1.
Patient Demographics and Clinical Characteristics
| Characteristic | FACTT (n = 306) | HMC SIRS (n = 241) |
|---|---|---|
| Patient age, mean (SD) | 50 (15) | 56 (15) |
| Male patients, n (%) | 157 (51.3) | 172 (71.4) |
| VFDs, mean (SD) | 14 (10) | 13 (11) |
| VFDs, median (IQR) | 18 (0–22) | 17 (0–23) |
| 28-d mortality, n (%) | 56 (18.3) | 59 (24.5) |
| APACHE III mean score (SD) | 92 (29) | 77 (25) |
| ARDS risk factor, n (%)* | ||
| Aspiration | 52 (17.0) | 53 (22.0) |
| Pneumonia | 138 (45.1) | 97 (40.3) |
| Sepsis | 67 (21.9) | 208 (86.3) |
| Trauma | 24 (7.8) | 0 |
| Multiple Transfusions | 4 (1.3) | 8 (3.3) |
| Other | 21 (6.8) | 26 (10.8) |
| Comorbidities, n (%) | ||
| Diabetes | 55 (18) | 62 (26) |
| HIV or AIDS | 15 (5) | 0 |
| Cirrhosis | 7 (2) | 36 (15) |
| Solid tumors | 4 (1) | 0 |
| Leukemia/Lymphoma | 6 (2) | 0 |
| Immunosuppression | 23 (7) | 0 |
Definition of abbreviations: APACHE = Acute Physiology and Chronic Health Evaluation; ARDS = acute respiratory distress syndrome; FACTT = Fluid and Catheter Treatment Trial; HMC = Harborview Medical Center; IQR = interquartile range; SIRS = systemic inflammatory response syndrome; VFDs = ventilator-free days.
*
Recorded as primary risk factor in FACTT and as present or not in HMC SIRS.