Table 3.
Mitogen-activated Protein Kinase Kinase Kinase 1 Single-Nucleotide Polymorphism Genotype Associations with Ventilator-Free Days in the Fluid and Catheter Treatment Trial and Harborview Medical Center Systemic Inflammatory Response Syndrome Cohorts
| SNP | VFDs Rare Allele Mean (±SD) | VFDs Common Allele Mean (±SD) | β (±SD) | P Value (Recessive) | FDR |
|---|---|---|---|---|---|
| FACTT cohort | |||||
| rs832582 | 8.3 (9.1) | 14.2 (9.7) | −6.1 (2.4) | 0.01 | 0.06 |
| rs832583 | 9.5 (9.2) | 14.1 (9.7) | −4.7 (2.6) | 0.07 | 0.24 |
| rs702689 | 11.8 (9.6) | 14.2 (9.7) | −2.5 (1.8) | 0.16 | 0.41 |
| rs726501 | 20.3 (2.6) | 13.9 (9.8) | 7.4 (5.5) | 0.18 | 0.36 |
| rs866223 | 13.3 (9.6) | 14.2 (9.7) | −0.6 (1.5) | 0.68 | 1.00 |
| rs1867731 | 13.3 (9.6) | 14.0 (9.8) | −0.6 (1.5) | 0.71 | 1.00 |
| rs832575 | 12.6 (9.6) | 14.1 (9.7) | −0.9 (3.2) | 0.78 | 0.98 |
| rs33330 | 15.9 (9.4) | 14.1 (9.6) | 0.3 (2.3) | 0.90 | 1.00 |
| rs33323 | 13.6 (9.5) | 14.0 (9.8) | −0.2 (1.5) | 0.92 | 0.92 |
| HMC SIRS cohort | |||||
| rs832582 | 0 (0) | 13.5 (10.4) | −15.1 (4.6) | < 0.01 | < 0.01 |
Definition of abbreviations: β = change in ventilator-free days of homozygotes for the rare allele from carriers of the common allele (recessive model); FACTT = Fluid and Catheter Treatment Trial; FDR = false discovery rate; HMC = Harborview Medical Center; SIRS = Systemic Inflammatory Response Syndrome; SNP = single-nucleotide polymorphism; VFD = ventilator-free days.