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Reduced miRNA-KEGG pathway interaction network, showing all genes within pathways that were targeted by at least two of the eight circulating signature miRNAs. Square nodes represent miRNAs, and circles represent target genes. The major hubs of interaction within the network of targeted KEGG pathways appear to be hsa-miR-128-3p, hsa-miR-4306, hsa-miR-30e-3p, and hsa-miR-342-5p through ALDH9A1, NUFIP2, and ZNF385A (each with three degrees of interaction).
