Table 3.

Hematological parameters of female rats in chronic toxicity test

Treaments	Time	Control	JYG-H	JYG-M	JYG-L
			7.5 g/kg	3.75 g/kg	1.875 g/kg
WBC	3 month	3.99 ± 1.44	3.46 ± 0.58	3.81 ± 0.49	4.04 ± 2.26
(× 109/L)	6 month	2.41 ± 1.31	1.95 ± 0.42	2.00 ± 0.79	1.90 ± 0.32
	1 month recovery	4.58 ± 1.82	4.86 ± 1.96	4.42 ± 2.22	4.43 ± 0.88
RBC	3 month	7.99 ± 0.42	7.38 ± 0.28*	7.84 ± 0.29	7.91 ± 0.48
(× 1012/L)	6 month	7.55 ± 1.19	7.71 ± 0.25	7.84 ± 0.52	8.03 ± 0.42
	1 month recovery	8.60 ± 0.35	8.35 ± 0.79	8.57 ± 0.44	8.41 ± 0.28
HGB	3 month	15.26 ± 0.61	14.40 ± 0.44*	14.86 ± 0.54	15.24 ± 0.86
(g/L)	6 month	14.30 ± 2.11	14.66 ± 0.89	14.64 ± 0.82	15.00 ± 0.43
	1 month recovery	15.24 ± 0.85	15.24 ± 0.68	15.50 ± 0.88	14.86 ± 0.60
PLT	3 month	1264 ± 54	1254 ± 210	1196 ± 106	1207 ± 172
(× 109/L)	6 month	1209 ± 347	1099 ± 120	1128 ± 110	1109 ± 156
	1 month recovery	1195 ± 140	1210 ± 198	1179 ± 98	1137 ± 121
NEUT	3 month	0.91 ± 0.62	0.98 ± 0.15	0.91 ± 0.13	0.94 ± 0.54
(× 109/L)	6 month	0.84 ± 0.57	0.66 ± 0.24	0.58 ± 0.16	0.58 ± 0.14
	1 month recovery	1.45 ± 0.58	1.65 ± 0.59	1.13 ± 0.65	1.30 ± 0.30
LYMPH	3 month	2.67 ± 1.08	2.15 ± 0.52	2.57 ± 0.40	2.77 ± 1.55
(× 109/L)	6 month	1.14 ± 0.47	1.10 ± 0.25	1.17 ± 0.54	1.11 ± 0.22
	1 month recovery	2.72 ± 1.28	2.75 ± 1.55	2.76 ± 1.57	2.69 ± 0.78
MONO	3 month	0.19 ± 0.10	0.22 ± 0.08	0.18 ± 0.07	0.20 ± 0.13
(× 109/L)	6 month	0.14 ± 0.13	0.09 ± 0.04	0.13 ± 0.13	0.11 ± 0.05
	1 month recovery	0.18 ± 0.12	0.23 ± 0.15	0.19 ± 0.15	0.22 ± 0.14

JYG-H, JYG-M,JYG-L Jueyin granules high-dose, medium dose, low-dose group, respectively. WBC total white blood cell count, RBC red blood cell, HGB hemoglobin, PLT blood platelet, Neut neutrophil, Lymph lymphocyte, Mono mononucleosis. The values are expressed as mean ± SEM (n = 10 rats for 3 months; n = 17–19 rats for 6 months; n = 10 rats for 1 month recovery). * Significantly different from control group (p < 0.05)