Table 4.

Hematological parameters of male rats in chronic toxicity test

Treaments	Time	Control	JYG-H	JYG-M	JYG-L
			7.5 g/kg	3.75 g/kg	1.875 g/kg
WBC	3 month	5.00 ± 1.01	8.27 ± 3.50	5.82 ± 1.28	6.81 ± 1.10
(× 109/L)	6 month	6.23 ± 2.20	6.06 ± 3.20	5.55 ± 1.23	5.52 ± 1.64
	1 month recovery	2.44 ± 1.30	2.36 ± 1.05	2.78 ± 0.85	2.33 ± 1.21
RBC	3 month	8.42 ± 0.67	8.06 ± 0.23	8.37 ± 0.16	8.58 ± 0.21
(× 1012/L)	6 month	8.80 ± 0.43	8.16 ± 0.51*	8.33 ± 0.47*	8.70 ± 0.39
	1 month recovery	7.05 ± 0.65	7.92 ± 0.76	7.57 ± 0.53	7.06 ± 0.79
HGB	3 month	14.56 ± 0.68	14.76 ± 0.36	15.02 ± 0.23	15.06 ± 0.42
(g/L)	6 month	15.14 ± 0.37	14.51 ± 0.78	14.72 ± 0.76	15.21 ± 0.49
	1 month recovery	13.26 ± 1.14	15.10 ± 1.01*	14.18 ± 1.09	13.14 ± 1.38
PLT	3 month	1214 ± 164	1108 ± 132	1080 ± 79	1186 ± 83
(× 109/L)	6 month	1134 ± 172	1182 ± 202	1102 ± 213	1210 ± 114
	1 month recovery	855 ± 314	897 ± 185	814 ± 238	759 ± 399
NEUT	3 month	1.53 ± 0.65	2.61 ± 1.69	1.51 ± 0.76	1.91 ± 0.70
(× 109/L)	6 month	1.61 ± 0.56	2.01 ± 1.13	1.71 ± 0.47	1.65 ± 0.81
	1 month recovery	0.74 ± 0.31	0.67 ± 0.20	0.93 ± 0.08	1.09 ± 0.86
LYMPH	3 month	2.91 ± 1.42	4.89 ± 1.89	3.78 ± 1.88	4.16 ± 0.62
(×109/L)	6 month	3.84 ± 1.55	3.34 ± 1.86	3.27 ± 0.97	3.36 ± 1.48
	1 month recovery	1.43 ± 0.91	1.39 ± 0.71	1.50 ± 0.71	0.99 ± 0.42
MONO	3 month	0.40 ± 0.24	0.58 ± 0.20	0.38 ± 0.17	0.53 ± 0.16
(×109/L)	6 month	0.49 ± 0.33	0.32 ± 0.24	0.29 ± 0.14	0.26 ± 0.15*
	1 month recovery	0.12 ± 0.07	0.19 ± 0.15	0.24 ± 0.11	0.15 ± 0.09

JYG-H, JYG-M, JYG-L Jueyin granules high-dose, medium dose, low-dose group, respectively, WBC total white blood cell count, RBC red blood cell, HGB hemoglobin, PLT blood platelet, Neut neutrophil, Lymph lymphocyte, Mono mononucleosis. The values are expressed as mean ± SEM (n = 10 rats for 3 months; n = 17–19 rats for 6 months; n = 10 rats for 1 month recovery). *Significantly different from control group (p < 0.05)