Table 5.
Correlations between immunohistological findings and lung function parameters (n = 33)
| Density of nodules | Density of cysts | VEGF-D | MMP-9 | mTOR | D2-40 | |
|---|---|---|---|---|---|---|
| FEV1 (%predicted) |
r = −0.51 p = 0.003 |
r = −0.58 p < 0.001 |
r = − 0.60 p < 0.001 |
r = − 0.62 p < 0.001 |
r = − 0.55 p = 0.002 |
ns |
| DLco (%predicted) |
r = − 0.68 p < 0.001 |
r = − 0.53 p = 0.003 |
r = − 0.51 p = 0.004 |
r = − 0.66 p < 0.001 |
ns |
r = − 0.48 p = 0.008 |
ns not significant, DLCO diffusion capacity for carbon monoxide, D2-40 podoplanin, FEV1 forced expiratory volume in the first second, MMP-9 metalloproteinase 9, mTOR mammalian target of rapamycin, VEGF-D vascular endothelial growth factor-D