Fig. 6.

Mst1 regulated mitochondrial fission via the JNK-Drp1 pathway. a–d Western blotting was performed to analyze the signaling pathways. SP600125 (SP) was used to inhibit JNK activation (WT + SP). Anisomycin (Ani), an activator of JNK, was applied in Mst1-knockout cells to reactivate the JNK (Mst1^KO + Ani). e and f Mitochondrial fission and mitochondrial length were measured with JNK activation and inhibition. *p < 0.05 vs. ctrl group, ^#p < 0.05 vs. WT-cell+hypoxia, ^†p < 0.05 vs. Mst1^KO-cell+hypoxia