Table 3.
Summary of the results
| MIV | MIV + collagenase | MIV + collagenase + GF | MACI | Control | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subject No | 1 | 2 | 3 | AVG10 | 5 | 6 | 7 | 8 | AVG | 9 | 11 | 12 | AVG | 14 | 15 | 16 | AVG | 17 | 18 | 19 | AVG |
| Macroscopic score | 8 | 7 | 4 | 6 | 6 | 5 | 5 | 5 | 5 | 3 | 5 | 3 | 4 | 7 | 5 | 4 | 5 | 3 | 3 | 3 | 3 |
| Histologic score: lesion1 | 10 | 8 | 8 | 9 | 6 | 8 | 7 | 7 | 7 | 8 | 8 | 7 | 8 | 10 | 9 | 8 | 9 | 2 | 2 | 2 | 2 |
| Histologic score: intact2 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 |
| Histologic score: patella3 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 |
| GAG lesion4 | 11.5 | 11.7 | 11.3 | 11.50 | 11.0 | 12.2 | 11.6 | 10.9 | 11.43 | 10.8 | 9.9 | 7.6 | 9.43 | 11.8 | 12.1 | 11.9 | 11.93 | 10.4 | 10.5 | 10.4 | 10.43 |
| GAG intact5 | 9.9 | 10.7 | 10.1 | 10.23 | 9.5 | 10.0 | 12.6 | 10.9 | 10.75 | 9.8 | 11.3 | 9.7 | 10.27 | 10.2 | 10.3 | 9.9 | 10.13 | 11.7 | 11.4 | 11.8 | 11.63 |
| GAG patella6 | 11.0 | 10.9 | 10.8 | 10.90 | 11.5 | 11.9 | 10.8 | 11.0 | 11.30 | 11.8 | 10.6 | 11.9 | 11.43 | 11.6 | 11.0 | 11.8 | 11.47 | 11.5 | 11.4 | 11.4 | 11.43 |
| Collagen type II: lesion7 | 22.5 | 34.7 | 20.6 | 25.93 | 9.2 | 10.0 | 8.6 | 8.0 | 8.95 | 7.5 | 6.7 | 6.4 | 6.87 | 41.8 | 40.0 | 41.5 | 41.10 | 2.5 | 2.4 | 2.5 | 2.47 |
| Collagen type II: intact8 | 9.0 | 9.3 | 7.3 | 8.53 | 12.6 | 6.7 | 6.7 | 8.9 | 8.73 | 11.3 | 6.3 | 8.8 | 8.80 | 6.7 | 6.2 | 9.4 | 7.43 | 8.3 | 8.5 | 8.0 | 8.27 |
| Collagen type II: patella9 | 8.4 | 7.9 | 7.8 | 8.03 | 8.9 | 9.2 | 7.7 | 8.6 | 8.6 | 7.9 | 8.6 | 9.1 | 8.53 | 8. | 7.8 | 8.2 | 8.30 | 8.5 | 8.6 | 8.8 | 8.63 |
1Histomorphometric score of the experimental lesion area
2Histomorphometric score of the intact cartilage obtained from the contralateral knee
3Histomorphometric score of the patellar cartilage obtained from the ipsilateral knee
4Experimental lesion area tissue glycosaminoglycan concentration (μg/mL)
5Intact cartilage obtained from the contralateral knee tissue glycosaminoglycan concentration (μg/mL)
6Patellar cartilage obtained from the ipsilateral knee tissue glycosaminoglycan concentration (μg/mL)
7Experimental lesion area tissue type II collagen concentration (ng/mL)
8Intact cartilage obtained from the contralateral knee tissue type II collagen concentration (ng/mL)
9Patellar cartilage obtained from the ipsilateral knee tissue type II collagen concentration (ng/mL)
10Group average value