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. 2018 May 8;9:18. doi: 10.1186/s13293-018-0177-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Sex differences in O₃-induced lung miRNA expression. a Cluster analysis of 84 miRNAs expressed in lung extracts obtained from male and female mice following exposure to 2 ppm of O₃ for 3 h. b Differentially expressed miRNAs in male and female lung extracts. Results are expressed as female miRNA expression levels relative to male miRNA expression levels. M males (n = 8), F females (n = 19), O3_M males exposed to ozone, O3_D1 females exposed to ozone in diestrus 1, O3_D2 females exposed to ozone in diestrus 2, O3_P females exposed to ozone in proestrus, O3_E females exposed to ozone in estrus