Table 2.
Summary obtained from IPA analysis of FA and O3 exposed male and female mice
| Males | Females | ||||
|---|---|---|---|---|---|
| A. Genes targeted by differentially expressed miRNAs | |||||
| ARHGEF38 Cg CPEB2 CPEB3 ENTPD7 EPHB6 FAM35A GAREM1 GPR63 Gulo |
IL6 KIAA1328 MIGA1 NT5DC1 PLAT RFX7 SECISBP2L SKIDA1 |
SLC38A1 TMCC1 TMEM110 MEM55A TSPAN13 UTS2B XKR8 ZCCHC11 |
APCDD1 ARHGAP12 BTG1 C2orf15 CMTR2 COX8C DYNC1LI2 ENPP5 FBXO48 |
FICD Gulo IL10RB INSR MBNL1 PAPD4 PLSCR4 PXK RP11_65D242 |
RRAGD SLC10A3 SMOC1 SNX2 SOCS5 STIM2 STX6 TMEM170B ULK2 |
| B. Differences in top diseases and biofunctions | |||||
| Diseases and disorders | P value | Diseases and disorders | P value | ||
| Gastrointestinal disease | 4.98E−02 to 3.39E−07 | Cancer, organismal injury and abnormalities | 4.85E−02 to 2.22E−10 | ||
| Inflammatory disease | 4.06E−02 to 3.39E−07 | Reproductive system disease | 3.24E−02 to 2.22E−10 | ||
| Inflammatory response | 4.06E−02 to 3.39E−07 | Endocrine system disease | 3.84E−02 to 2.22E−06 | ||
| C. Top molecular and cellular functions | |||||
| Molecular and cellular functions | P value | Molecular and cellular functions | P value | ||
| Cell cycle | 1.26E−02 to 3.46E−05 | Cellular development | 4.06E−02 to 2.54E−04 | ||
| Cell death and survival | 4.95E−02 to 8.00E−05 | Cellular growth and proliferation | 4.06E−02 to 2.54E−04 | ||
| Cellular movement | 4.11E−02 to 9.68E−05 | Cell morphology | 1.10E−02 to 5.62E−04 | ||
| D. Top physiological system development and function | |||||
| Development and function | P value | Development and function | P value | ||
| Digestive system development and function | 1.51E−02 to 3.39E−07 | Organismal development | 4.85E−02 to 2.22E−10 | ||
| Hepatic system development and function | 1.51E−02 to 3.39E−07 | Endocrine system disorders | 3.84E−02 to 2.22E−06 | ||
| Organ development | 4.98E−02 to 3.39E−07 | Reproductive system development and function | 3.24E−02 to 2.22E−10 | ||
| E. Top associated network functions | |||||
| Associated network functions | Score | Associated network functions | Score | ||
| Digestive system development and function, gastrointestinal disease, hepatic system development and function | 17 | Cancer, organismal injury and abnormalities, reproductive system disease | 14 | ||