Table 2.
Association between DNA methylation and delayed recall for significant CpGs in the full analysis sample (N = 282)a
| PVRL2 | TOMM40 | APOE | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cg26717215 | cg08583001 | cg11670000 | cg22024783 | cg12271581 | cg04406254 | cg01032398 | cg18768621 | |||||||||
| Region feature(s)b | Promoter, CGI | Promoter, CGI | CGI shelf | Promoter, CGI | Promoter, CGI | Promoter, CGI shelf | Promoter, CGI shelf | CGI shelf | ||||||||
| β (q) | ∆R2 | β (q) | ∆R 2 | β (q) | ∆R2 | β (q) | ∆R2 | β (q) | ∆R2 | β (q) | ∆R2 | β (q) | ∆R2 | β (q) | ∆R2 | |
| Model 1c | −0.66 (0.048) |
0.03 | − 0.37 (0.086) |
0.02 | − 0.20 (0.086) |
0.02 | −0.40 (0.086) |
0.02 | −0.43 (0.086) |
0.02 | −0.23 (0.086) |
0.02 | −0.38 (0.012) |
0.04 | −0.32 (0.048) |
0.03 |
| Model 2d | −0.62 (0.058) |
0.03 | −0.42 (0.058) |
0.03 | −0.19 (0.120) |
0.02 | −0.41 (0.086) |
0.02 | −0.39 (0.121) |
0.02 | −0.23 (0.086) |
0.02 | −0.35 (0.026) |
0.03 | −0.29 (0.058) |
0.02 |
aIn the full sample, 282 participants had non-missing delayed recall measures. Only CpG sites that had a significant association with delayed recall (FDR q < 0.1) after adjustment for age and sex (Model 1) are shown. β (q) represents the estimated change in delayed recall score for a 1% increase in methylation level of the CpG site, after adjustment for model covariates, and its associated q-value. ∆R2 is the additional percent variation in delayed recall explained by the CpG site in the model, compared to the reduced model with only covariates
bRegion feature(s) are from Illumina annotation. “Promoter” = within 1.5 kb before the transcription start site of a gene; “CGI” = within a CpG island; “CGI shelf” = 2-4 kb from CGI
cModel 1: Delayed recall = CpG methylation + age + sex
dModel 2: Delayed recall = CpG methylation + age + sex + education