Table 3.
Top ranked SNPs associated with DME and PDR. SNPs with p < 1.0 × 10− 5 for each phenotype are shown
| Phenotype | Chr | SNP | Position in hg 38 (bp) | Minor allele | MAF cases | MAF controls | OR (95% CI) | P | Nearest gene |
|---|---|---|---|---|---|---|---|---|---|
| DME | 2 | rs1990145 | 75,650,524 | A | 0.364 | 0.268 | 2.02 (1.50, 2.72) | 4.10 × 10− 6 | MRPL19 |
| 13 | rs4771506 | 105,843,651 | C | 0.325 | 0.263 | 1.97 (1.46, 2.64) | 6.94 × 10− 6 | LINC00343 | |
| PDR | 5 | rs918519 | 159,399,349 | T | 0.163 | 0.231 | 0.35 (0.22, 0.54) | 3.87 × 10− 6 | LOC285626 |
| 14 | rs1158314 | 79,961,389 | G | 0.515 | 0.400 | 2.16 (1.56, 3.00) | 4.01 × 10− 6 | NRXN3 | |
| 14 | rs8004963 | 79,958,817 | C | 0.515 | 0.400 | 2.16 (1.56, 3.00) | 4.01 × 10− 6 | NRXN3 | |
| 14 | rs11159428 | 79,950,890 | T | 0.512 | 0.399 | 2.13 (1.54, 2.95) | 5.63 × 10−6 | NRXN3 | |
| 5 | rs918520 | 159,399,302 | C | 0.131 | 0.211 | 0.34 (0.21, 0.54) | 6.66 × 10− 6 | LOC285626 |
Odds ratios (OR) calculated with respect to the minor allele. P values are adjusted for age, duration of diabetes, sex, hypertension, nephropathy (defined as microalbuminuria or worse), HbA1c and the first 3 principal components. Chr chromosome, MAF minor allele frequency