Table 1.
Radiosynthesis characteristics of the different 18F labeled bile acids. The overall synthesis time was 100 minutes. n.d.c. RY: nondecay corrected radiochemical yield. RP: radiochemical purity. Data are mean ± SD.
| n.d.c. RY (%) (n = 3) |
18F labeling of precursor (%) (n = 3) |
RP (%) | LogD (n = 3) |
|
|---|---|---|---|---|
| 3α-[18F]FCA | 10.56 ± 2.02 | 30.31 ± 1.28 | >99 | 0.92 ± 0.17 |
| 3β-[18F]FGCA | 4.28 ± 0.39 | 11.51 ± 2.55 | >99 | 0.011 ± 0.037 |
| 3β-[18F]FCDCA | 9.57 ± 1.51 | 28.27 ± 5.02 | >99 | 1.42 ± 0.16 |
| 12β-[18F]FCA | <0.5 | 2.82 ± 1.14 | NA | NA |
| 7β-[18F]FCA | <0.5 | 1.23 ± 0.26 | NA | NA |