Table 3.
Metrics of the 18F labeled bile acids time-activity curves. The values are expressed as mean ± SD (n = 3). Significant differences compared to the 3β-[18F]FCA values are marked with ∗. A p value ≤ 0.05 was considered significant. GBI = gallbladder and intestines; AB = arterial blood.
| 3β-[18F]FCA | 3α-[18F]FCA | 3β-[18F]FGCA | 3β-[18F]FCDCA | |
|---|---|---|---|---|
| AUC liver (% ID·min) | 1785 ± 194 | 1065 ± 171∗ | 1907 ± 58 | 2449 ± 111∗ |
| Max% ID liver (%) | 63.80 ± 2.61 | 58.58 ± 3.19 | 63.58 ± 1.84 | 51.01 ± 3.94∗ |
| Time-to-peak liver (min) | 5.33 ± 0.24 | 3.33 ± 0.62∗ | 5.17 ± 0.62 | 10.17 ± 0.62∗ |
| AUC GBI (% ID·min) | 3499 ± 340 | 4184 ± 109∗ | 3021 ± 276 | 2515 ± 189∗ |
| Max% ID GBI (%) | 83.44 ± 9.27 | 88.70 ± 2.38 | 75.32 ± 6.30 | 60.93 ± 7.29∗ |
| AUC AB concentration (MBq·min/mL) | 13003 ± 1032 | 14007 ± 2150 | 10192 ± 1404 | 28437 ± 4380∗ |
| Biliary clearance (mL/min) | 0.46 ± 0.08 | 0.49 ± 0.10 | 0.47 ± 0.07 | 0.18 ± 0.04∗ |