Table 4. . K_d for isoquinoline analogs binding to FLT3, FLT3-ITD and FLT3 (D835V), determined via DiscoverX K_d Elect service.

	HSN286	HSN356	HSN334	HSN178	HSN248
FLT3	6.5 nM	1.3 nM	5.1 nM	53 nM	47 nM
FLT 3 (ITD)	27.6 nM	6.7 nM	19 nM	450 nM	330 nM
FLT3 (D835V)	120 nM	19 nM	120 nM	ND	ND

FLT3: FMS-like tyrosine kinase 3; ITD: Internaltandem duplication; ND: Not determined.