Table 4.

Prognostic factors for (a) any type of recurrence and (b) loco-regional recurrence

(a) Any type of recurrence
Univariable analysis
Characteristics	OR	95% CI	p value
N0 vs N+	3.241	1.191–4.567	< 0.001
Others vs AD	0.102	0.023–0.456	0.003
WD-MD vs PD	2.164	1.185–3.951	0.012
LVI Yes vs No	0.566	0.325–0.987	0.045
PNI Yes vs No	0.385	0.219–0.677	0.001
R0 vs close RM-R1	3.351	1.923–5.841	< 0.001
Multivariable analysis
Characteristics	OR	95% CI	p value
N0 vs N+	2.533	1.420–4.518	0.002
R0 vs close RM-R1	2.685	1.517–4.753	0.001
(b) loco-regional recurrence
Univariable analysis
Characteristics	OR	95% CI	p value
R0 vs close RM-R1	3.124	1.933–5.442	< 0.001
Multivariable analysis
Characteristics	OR	95% CI	p value
R0 vs close RM-R1	2.382	1.416–4.243	< 0.001

OR odds ratio, CI confidential interval, vs versus, N0 negative lymph node, N+ positive lymph node, AD adenocarcinoma, WD well differentiation, MD moderate differentiation, PD poor differentiation, LVI lymphovascular invasion, PNI perineural invasion, RM resection margin