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. 2018 Apr 24;2018:1271864. doi: 10.1155/2018/1271864

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Copyright © 2018 Baolong Qin et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Losartan downregulated NF-κB pathway activity and stone-related protein expression by attenuation of renal tubular cell oxidative stress. (a) NRK-52E cells were induced by COM (1 mM) for 6 h with or without losartan preincubation, and then intracellular ROS was detected by flow cytometry. The expression of NADPH oxidase subunits (Nox2 and Nox4) (b), NF-κB subunits (p50 and p65) (c), and stone-related proteins (OPN, CD44, and MCP-1) (d) was decreased in the COM + Ang II + losartan group compared with the COM + Ang II group in NRK-52E cells. (e) Losartan administration ameliorated the CaOx depositions (black arrow) compared with the rat kidneys of the hyperoxaluria group (Von Kossa staining, magnification: ×400). The data are expressed as mean ± SEM. ^∗P < 0.05 compared with the Ang II group and ^#P < 0.05 compared with the COM + Ang II group. ^∗#P < 0.05 compared with the Ang II group and the COM + Ang II group.