Table 1.

Evaluation of response using neuro-oncology criteria of tumor response for CNS tumors

Overall Response	Target lesion (up to 5 measurable lesions)	Non Target lesion	New lesion	Neurologic examination scale	Corticosteroid use
Complete response (CR)	None	None	No	+2, +1, 0, −1	No
Partial Response (PR)	≥ −50%	Non-enhancing, improved, unchanged	No	+2, +1, 0, −1	Stable (<25% increase from baseline)
Progression (PD)	≥ +25%	Worsened	Yes	−2	Increase (>25% increase from baseline)
Stable disease (SD)*

^*SD = Any other disease status not meeting criteria for CR, PR or PD; +2=definitely better, +1=possibly better, 0=unchanged, −1=possibly worse, −2=definitely worse.