Table 3.

Patupilone pharmacokinetic parameters in Cycles 1 and 3

	Cycle 1			Cycle 3
PK parameter	n	Mean	CV% mean	n	Mean	CV% mean
Cmax (ng/mL)	27	160.66	144.19	11	198.27	183.41
Cmin(ng/mL)	9	0.376	91.50	8	0.342	105.13
AUC0−∞ (ng*h/mL)	27	1415.57	73.87	-	-	-
AUC0−ταυ (ng*h/mL)	28	1543.83	63.80	11	1977.76	100.14
CL (L/h/m2)	28	6.857	74.78	-	-	-
Vss (L/m2)	28	754.97	88.33	-	-	-
t1/2(hours)	28	102.69	42.11	10	108.08	23.46
R	-	-	-	11	0.970	6.11

CV% mean= = coefficient of variation(%) = square-root(exp(variance for log transformed data)−1)*100, CL = clearance, V_ss=steady state volume of distribution, R=drug accumulation by AUC_{0−ταυ Dose 4}/ AUC_{0−ταυ Dose 1}