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Working model for ERK activation. Baseline levels of phospho-ERK oscillate at baseline. A stimulus activating the ERK pathway increase the level of activated ERK. In contrast, mice with overexpression of activated MEK1 have sustained increased activation, and mice with overexpression of DUSP6 have very low baseline and post-stimulus levels. Mice with deletion of DUSP6 appear to have increased baseline activation, but unchanged post stimulus levels.
