FIGURE 7.

Artocarpin inhibits xenograft tumor growth in SCID mice. (A,B) Mice were subcutaneously injected with U118 cells. When the tumors grew to 100 mm³, the mice were administered artocarpin (2 mg kg^-1) or vehicle once daily for 3 weeks. Tumor volume was determined at various times after implantation (n = 8–10). (C) Mouse body weights were measured at various times after tumor implantation. (D) Western blot analyses for Bax, Bcl-2, cleaved caspase-3, cleaved caspase-9, cleaved PARP, phospho-ERK1/2, and phospho-Akt levels in tumors with- and without artocarpin treatment. ^∗P < 0.05.