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. 2018 May 2;2(9):1000–1012. doi: 10.1182/bloodadvances.2017013953

Figure 1.

Figure 1.

The somatic mutations detected in HLA−granulocytes. (A) A summary of targeted sequencing of the 15 cases. Somatic mutations (red), nonsynonymous mutations of unknown significance (green), and synonymous mutations (pink) are shown. (B) The somatic mutations in HLA− granulocytes and HLA+ granulocytes (left, DNMT3A, ZRSR2 and TET2 mutations in case 1; top right, a DNMT3A mutation in case 2; bottom right, a CBL mutation in case 4). HLA+ granulocytes of cases 2 and 3 were not assessable due to the paucity of the cell populations. Two different TET2 frameshift mutations were detected in case 1’s HLA− granulocytes and HLA+ granulocytes, respectively. (C) The somatic mutations detected by whole-exome sequencing (WES) in 5 cases. del., deletion.