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. 2018 May 4;11:2519–2531. doi: 10.2147/OTT.S157255

Table 2.

Subgroup analysis of the difference in circulating adiponectin between patients with colorectal cancer and controls

Characteristics Subgroups Studies (number) WMD 95% CI pD I2 pH pE
Cancer subtype CRC 20 −0.736 −1.519 to 0.047 0.065 94.0% <0.001 0.514
CRA 10 −0.892 −1.573 to −0.211 0.010 80.1% <0.001 0.473
Colon 10 −1.073 −2.095 to −0.050 0.040 97.3% <0.001 0.403
Rectum 4 −0.681 −1.358 to −0.005 0.048 75.4% 0.007 0.778
Region East Asia 6 −1.707 −2.979 to −0.436 0.008 95.1% <0.001 0.213
America 10 −0.343 −0.599 to −0.087 0.009 36.7% 0.115 0.683
Europe 15 −0.749 −1.451 to −0.047 0.037 94.3% <0.001 0.541
Middle East 10 −0.787 −3.015 to 1.442 0.489 97.1% <0.001 0.787
Study design Retrospective 22 −1.179 −2.536 to 0.177 0.088 96.2% <0.001 0.489
Nested 19 −0.266 −0.380 to −0.152 <0.001 12.4% 0.303 0.409
Matching status NA 21 −1.472 −2.452 to −0.491 0.003 96.1% <0.001 0.411
Yes 20 −0.099 −0.389 to 0.191 0.504 79.0% <0.001 0.693
Sample source Plasma 18 −0.714 −1.358 to −0.070 0.030 95.1% <0.001 0.783
Serum 23 −0.803 −1.430 to −0.176 0.012 93.3% <0.001 0.303
Sample size (median) ≤230 21 −1.189 −2.609 to 0.231 0.101 96.4% <0.001 0.511
>230 20 −0.271 −0.385 to −0.157 <0.001 12.1% 0.304 0.262
Gender Men 9 −0.671 −1.255 to −0.086 0.025 90.4% <0.001 0.536
Women 8 −0.329 −0.693 to 0.035 0.077 49.6% <0.001 0.206
BMI <25 kg/m2 7 −1.627 −3.092 to −0.163 0.029 92.1% <0.001 0.434
≥25 kg/m2 24 −0.527 −1.016 to −0.039 0.034 92.4% <0.001 0.611
WHR <0.9 m 5 −0.878 −1.798 to 0.043 0.062 94.7% <0.001 0.112
≥0.9 m 9 −0.522 −0.939 to −0.106 0.014 60.6% 0.009 0.496
DM Without 12 −1.385 −3.003 to 0.233 0.093 96.1% <0.001 0.349
TNM stage I–II 9 −1.280 −2.115 to −0.446 0.003 90.1% <0.001 0.103
III–IV 9 −1.196 −2.033 to −0.358 0.005 92.6% <0.001 0.219

Notes: pD, the p-value for WMD; I2, inconsistency index; pH, the p-value for heterogeneity; pE, the p-value for Egger’s regression asymmetry test.

Abbreviations: WMD, weighted mean difference; CI, confidence interval; CRC, colorectal cancer; CRA, colorectal adenoma; BMI, body mass index; WHR, waist–hip ratio; DM, diabetes mellitus; TNM, tumor node metastasis; NA, not available.