Table 3.

Associations between CT morphologic features and pathologic types

Characteristics	ADC, n=99	SQCC, n=95	SCLC, n=108	p-value	p-value, ADC vs SQCCa	p-value, ADC vs SCLCa	p-value, SQCC vs SCLCa
Maximal lesion sizeb (cm)	4.7 (2.4–13.9)	4.7 (1.4–11.1)	5.7 (3.1–17.5)	0.001	0.77	0.003	0.001
Location				0.86	–	–	–
Left	47	49	55
Right	52	46	53
Lobulated margin	25	20	33	0.32	–	–	–
Spiculated margin	20	22	11	0.04	0.73	0.05	0.01
Air bronchogram	9	3	1	0.02c	0.13	0.008c	0.34c
Bronchovascular bundle convergence	13	7	1	0.002	0.24	<0.001	0.03c
Pulmonary infarction	7	4	38	<0.001	0.54	<0.001	<0.001
Lymphangitic carcinomatosis	9	1	7	0.03c	0.02c	0.61	0.07c
Pulmonary emphysema	12	29	23	0.007	0.003	0.10	0.15
Mediastinal lymphadenopathy	82	62	84	0.01	0.006	0.39	0.06
Contralateral hilum lymphadenopathy	23	3	9	<0.001	<0.001	0.004	0.14
Ipsilateral hilum lymphadenopathy	71	57	76	0.16	–	–	–
Contralateral lung metastasis	29	6	4	<0.001	<0.001	<0.001	0.52c
Pleural nodules	37	5	12	<0.001	<0.001	<0.001	0.20
Interlobular fissure pleural metastasis	17	0	2	<0.001	<0.001	<0.001	0.50c
Pleural effusion	55	24	46	<0.001	<0.001	0.07	0.01
Vascular involvement	32	39	83	<0.001	0.23	<0.001	<0.001

Notes:

^aBonferroni correction in which p<0.0167 is significant.

^bContinuous quantitative data are presented as median and range.

^cFisher’s exact test.

Abbreviations: ADC, adenocarcinoma; CT, computed tomography; SCLC, small cell lung cancer; SQCC, squamous cell carcinoma.