Fig. 6.

Activation of IRt/PCRt neurons are required for hypothalamic NPY-induced inhibition of BAT thermogenesis, metabolism and tachycardia. a, b Skin cooling-evoked increases in BAT thermogenesis, whole body metabolism (expired CO₂) and HR were inhibited by an NPY nanoinjection into the rat PVH following bilateral nanoinjections of saline into the IRt/PCRt (a), whereas bilateral nanoinjections of muscimol to inactivate IRt/PCRt neurons prevented the inhibitory effects of NPY (b). AP, arterial pressure. Modified from Nakamura et al. [69] with permission