Table 2.
Groups | Genotype
|
Whole
|
Drinking
|
Non-drinking
|
Crude OR (95% CI) | Crude P-value | Adjusted OR (95% CI) | Adjusted P-value* | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALDH2 | CYP2E1 | HCC | Control | HCC | Control | HCC | Control | |||||
G/G | 149 | 152 | 1.00 | 0.469 | 1.00 | 0.999 | ||||||
G/A | 121 | 119 | 1.04 (0.74–1.46) | 0.833 | 0.99 (0.59–1.65) | 0.967 | ||||||
A/A | 30 | 21 | 1.46 (0.80–2.66) | 0.220 | 1.00 (0.40–2.48) | 0.996 | ||||||
G/A+A/A | 151 | 140 | 1.10 (0.80–1.52) | 0.561 | 0.99 (0.61–1.62) | 0.972 | ||||||
C1/C1 | 203 | 196 | 1.00 | 0.546 | 1.00 | 0.381 | ||||||
C1/C2 | 87 | 81 | 1.04 (0.72–1.49) | 0.843 | 0.67 (0.38–1.19) | 0.171 | ||||||
C2/C2 | 10 | 15 | 0.64 (0.28–1.47) | 0.295 | 0.77 (0.22–2.70) | 0.684 | ||||||
C1/C2+C2/C2 | 97 | 96 | 0.98 (0.69–1.38) | 0.888 | 0.69 (0.40–1.18) | 0.170 | ||||||
i | G/G | C1/C1 | 104 | 96 | 1.00 | 0.397 | 1.00 | 0.160 | ||||
ii | G/G | C1/C2+C2/C2 | 45 | 56 | 0.74 (0.46–1.20) | 0.223 | 0.42 (0.20–0.90) | 0.025 | ||||
iii | G/A+A/A | C1/C1 | 99 | 100 | 0.91 (0.62–1.35) | 0.653 | 0.72 (0.40–1.31) | 0.287 | ||||
iiii | G/A+A/A | C1/C2+C2/C2 | 52 | 40 | 1.20 (0.73–1.97) | 0.472 | 0.83 (0.39–1.77) | 0.626 | ||||
1 | G/G | C1/C1 | 70 | 79 | 1.00 | 0.067 | 1.00 | 0.137 | ||||
2 | G/G | C1/C2+C2/C2 | 32 | 45 | 0.80 (0.46–1.40) | 0.438 | 0.45 (0.19–1.06) | 0.068 | ||||
3 | G/A+A/A | C1/C1 | 74 | 63 | 1.33 (0.83–2.11) | 0.235 | 1.13 (0.56–2.26) | 0.740 | ||||
4 | G/A+A/A | C1/C2+C2/C2 | 38 | 23 | 1.87 (1.01–3.43) | 0.045 | 1.33 (0.54–3.28) | 0.538 | ||||
! | G/G | C1/C1 | 34 | 17 | 1.00 | 0.043 | 1.00 | 0.053 | ||||
! ! | G/G | C1/C2+C2/C2 | 13 | 11 | 0.59 (0.22–1.59) | 0.299 | 0.35 (0.07–1.72) | 0.197 | ||||
! ! ! | G/A+A/A | C1/C1 | 25 | 37 | 0.34 (0.16–0.73) | 0.006 | 0.20 (0.06–0.68) | 0.010 | ||||
! ! ! ! | G/A+A/A | C1/C2+C2/C2 | 14 | 17 | 0.41 (0.17–1.03) | 0.058 | 0.20 (0.04–0.96) | 0.045 |
Note:
P adjustment for race and HBsAg.
Abbreviations: HCC, hepatocellular carcinoma; OR, odds ratio; CI, confidence interval.