Table 2.

Joint-effects analysis between ALDH2 or CYP2E1 and drinking status on HCC susceptibility

Groups	Genotype		Whole		Drinking		Non-drinking		Crude OR (95% CI)	Crude P-value	Adjusted OR (95% CI)	Adjusted P-value*
	ALDH2	CYP2E1	HCC	Control	HCC	Control	HCC	Control
	G/G		149	152					1.00	0.469	1.00	0.999
	G/A		121	119					1.04 (0.74–1.46)	0.833	0.99 (0.59–1.65)	0.967
	A/A		30	21					1.46 (0.80–2.66)	0.220	1.00 (0.40–2.48)	0.996
	G/A+A/A		151	140					1.10 (0.80–1.52)	0.561	0.99 (0.61–1.62)	0.972
		C1/C1	203	196					1.00	0.546	1.00	0.381
		C1/C2	87	81					1.04 (0.72–1.49)	0.843	0.67 (0.38–1.19)	0.171
		C2/C2	10	15					0.64 (0.28–1.47)	0.295	0.77 (0.22–2.70)	0.684
		C1/C2+C2/C2	97	96					0.98 (0.69–1.38)	0.888	0.69 (0.40–1.18)	0.170
i	G/G	C1/C1	104	96					1.00	0.397	1.00	0.160
ii	G/G	C1/C2+C2/C2	45	56					0.74 (0.46–1.20)	0.223	0.42 (0.20–0.90)	0.025
iii	G/A+A/A	C1/C1	99	100					0.91 (0.62–1.35)	0.653	0.72 (0.40–1.31)	0.287
iiii	G/A+A/A	C1/C2+C2/C2	52	40					1.20 (0.73–1.97)	0.472	0.83 (0.39–1.77)	0.626
1	G/G	C1/C1			70	79			1.00	0.067	1.00	0.137
2	G/G	C1/C2+C2/C2			32	45			0.80 (0.46–1.40)	0.438	0.45 (0.19–1.06)	0.068
3	G/A+A/A	C1/C1			74	63			1.33 (0.83–2.11)	0.235	1.13 (0.56–2.26)	0.740
4	G/A+A/A	C1/C2+C2/C2			38	23			1.87 (1.01–3.43)	0.045	1.33 (0.54–3.28)	0.538
!	G/G	C1/C1					34	17	1.00	0.043	1.00	0.053
! !	G/G	C1/C2+C2/C2					13	11	0.59 (0.22–1.59)	0.299	0.35 (0.07–1.72)	0.197
! ! !	G/A+A/A	C1/C1					25	37	0.34 (0.16–0.73)	0.006	0.20 (0.06–0.68)	0.010
! ! ! !	G/A+A/A	C1/C2+C2/C2					14	17	0.41 (0.17–1.03)	0.058	0.20 (0.04–0.96)	0.045

Note:

^*P adjustment for race and HBsAg.

Abbreviations: HCC, hepatocellular carcinoma; OR, odds ratio; CI, confidence interval.