Table 3.

Joint-effects analysis between ALDH2 or CYP2E1 and drinking status on HCC susceptibility

Groups	Drinking status	Genotype	HCC (%) (n=300)	Control (%) (n=292)	Crude OR (95% CI)	Crude P-value	Adjusted OR (95% CI)	Adjusted P-value*
1	−	G/G	47	28	1.00	0.006	1.00	0.022
2	−	G/A+A/A	39	54	0.43 (0.23–0.80)	0.008	0.32 (0.13–0.79)	0.014
3	+/++	G/G	102	124	0.49 (0.29–0.84)	0.009	0.32 (0.15–0.69)	0.004
4	+/++	G/A+A/A	112	86	0.78 (0.45–1.34)	0.362	0.49 (0.23–1.07)	0.075
I	+	G/G	55	77	1.00	0.004	1.00	0.360
II	+	G/A+A/A	69	68	1.42 (0.88–2.30)	0.153	1.75 (0.85–3.58)	0.127
III	++	G/G	47	47	1.40 (0.82–2.38)	0.215	1.53 (0.68–3.42)	0.306
IV	++	G/A+A/A	43	18	3.34 (1.75–6.41)	<0.001	2.00 (0.78–5.12)	0.148
a	−	C1/C1	59	54	1.00	0.982	1.00	0.338
b	−	C1/C2+C2/C2	27	28	0.88 (0.46–1.68)	0.704	0.69 (0.25–1.85)	0.456
c	+/++	C1/C1	144	142	0.93 (0.60–1.44)	0.737	0.71 (0.37–1.37)	0.307
d	+/++	C1/C2+C2/C2	70	68	0.94 (0.57–1.55)	0.815	0.49 (0.23–1.05)	0.067
A	+	C1/C1	88	98	1.00	0.094	1.00	0.534
B	+	C1/C2+C2/C2	36	47	0.85 (0.51–1.44)	0.550	0.61 (0.28–1.34)	0.215
C	++	C1/C1	56	44	1.42 (0.87–2.31)	0.162	1.14 (0.55–2.37)	0.728
D	++	C1/C2+C2/C2	34	21	1.80 (0.97–3.34)	0.060	1.00 (0.39–2.57)	0.995

Notes:

^*P adjustment for race and HBsAg. −, Not drinking; +, drinking little; ++, drinking a lot.

Abbreviations: HCC, hepatocellular carcinoma; OR, odds ratio; CI, confidence interval.