Table 1.
Comparison of demographic, clinicopathologic, and laboratory data in cirrhosis- and noncirrhosis HCC groups
| Variables | Total, n=109 | Cirrhosis group, n=62 | Noncirrhosis group, n=47 | p |
|---|---|---|---|---|
| Age (years), median (range) | 66 (18–82) | 66 (42–82) | 65 (18–80) | 0.070 |
| Sex, n (%) | ||||
| Male | 65 (59.6) | 35 (56.5) | 30 (63.8) | 0.437 |
| Female | 44 (40.4) | 27 (43.5) | 17 (36.2 | |
| ASA, n (%) | ||||
| I/II | 62 (56.9) | 32 (51.6) | 30 (63.8) | 0.202 |
| III/IV | 47 (43.1) | 30 (48.4) | 17 (36.2) | |
| Etiology, n (%) | ||||
| HBV | 30 (27.5) | 30 (27.5) | – | |
| HCV | 23 (21.1) | 23 (21.1) | – | |
| Alcohol abuse | 6 (5.5) | 6 (5.5) | – | |
| Other (unknown) | 3 (2.8) | 3 (2.8) | – | |
| Liver steatosis | 17 (15.6) | – | 17 (36.2) | |
| Alcohol excess | 2 (1.8) | – | 2 (4.2) | |
| Adenoma alteration | 5 (4.6) | – | 5 (10.6) | |
| WBC (×109/L), median (range) | 6.7 (2–11) | 6.5 (2–10) | 7 (4–11) | 0.662 |
| Platelet (×109/L), median (range) | 210 (42–583) | 210 (42–427) | 218 (123–583) | 0.158 |
| NLR, median (range) | 1.95 (0.37–6.07) | 2.04 (0.63–6.07) | 1.74 (0.37–5.78) | 0.520 |
| PLR, median (range) | 107.5 (11.2–647.8) | 107.5 (20.1–266.9) | 98.4 (11.2–647.8) | 0.343 |
| Total bilirubin (mmol/L), median (range) | 12.5 (3.8–636) | 15 (3.8–636) | 11 (4–26) | 0.149 |
| ALT (IU/L), median (range) | 32 (6–166) | 35 (6–166) | 29 (11–158) | 0.311 |
| γGT (IU/L), median (range) | 59 (9–1185) | 68.5 (9–1185) | 53 (10–871) | 0.490 |
| Lesion number, n (%) | ||||
| Single | 95 (87.2) | 52 (83.9) | 43 (91.5) | 0.239 |
| Multiple | 14 (12.8) | 10 (16.1) | 4 (8.5) | |
| Major lesion size, n (%) | ||||
| <5 cm | 12 (11) | 7 (11.3) | 5 (10.6) | 0.914 |
| ≥5 cm | 97 (89) | 55 (88.7) | 42 (89.4) | |
| Operative time (min), median (range) | 240 (55–600) | 240 (55–600) | 300 (120–480) | 0.373 |
| Transection time (min), median (range) | 60 (15–210) | 60 (15–210) | 60 (15–210) | 0.745 |
| Hepatectomy, n (%) | ||||
| Anatomic | 52 (47.7) | 29 (46.8) | 23 (48.9) | 0.823 |
| Nonanatomic | 57 (52.3) | 33 (53.2) | 24 (51.1) | |
| Extent of resection, n (%) | ||||
| Major | 39 (35.8) | 20 (32.3) | 19 (40.4) | 0.378 |
| Minor | 70 (64.2) | 42 (67.7) | 28 (59.6) | |
| Intraoperative transfusion rate, n (%) | 7 (6.4) | 2 (3.2) | 5 (10.6) | 0.235 |
Abbreviations: γGT, gamma-glutamyl transferase; ALT, alanine aminotransferase; ASA, American Society of Anesthesiologists; HBV, hepatitis B virus; HCC, hepatocellular cancer; HCV, hepatitis C virus; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet to lymphocyte ratio; WBC, white blood cells.