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. 2018 May 4;10:1051–1059. doi: 10.2147/CMAR.S162932

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© 2018 Garbar et al. This work is published and licensed by Dove Medical Press Limited

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Relationship between ST6Gal-I and TILs in different breast cancer subtypes.

Notes: In HER2 tumors, low levels of ST6Gal-I are correlated with an increase in all lymphocyte subsets (*CD4: P = 0.01; **CD8: P = 0.02; ***CTL/NK: P = ns). On the right, statistical negative Spearmen’s correlations are documented for CD4 and CD8 positive T lymphocytes in HER2 breast carcinoma (regression line and 95% CI). For LUM and TN, we found no significant correlation. We conclude that high expression of ST6Gal-I in HER2 leads to reduced TILs.

Abbreviations: TILs, tumor-infiltrating lymphocytes; HER2, human epidermal growth factor receptor 2; CTL/NK; cytotoxic T lymphocytes/natural killer lymphocytes; LUM, luminal; TN, triple negative; ns, not significant.