. 2018 May 5;8(5):e020640. doi: 10.1136/bmjopen-2017-020640

Table 4.

Clinical outcomes measured in the MULTI sTUdy Diabetes rEsearch Consortium

Data sets	All-cause mortality	Cause of death	T2DM-related events*				Cardiac events*						Vascular events*		Liver disease	Ageing diseases	Depression
Data sets	All-cause mortality	Cause of death	T2DM	Renal failure†	Neuropathy‡	Retinopathy	CVD	Angina	CAD	CHF	MI	PCI/CABG	Hypertension	Stroke/TIA	Liver disease	Ageing diseases	Depression
ACCORD	+	+	+	+	+	+	+	+	+	+	+	+	+	+			+
AFFIRM	+	+					+			+	+	+	+	+
BARI 2D	+	+	+	+	+	+	+	+		+	+	+	+	+
ARIC	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
JHS	+	+	+	+	+	+	+	+	+	+	+	+	+	+			+
FHS cohort	+	+	+	+	+	+§	+	+	+	+	+	+	+	+		+	+
FHS offspring	+	+	+	+	+		+	+	+	+	+	+	+	+	+	+	+
FHS Gen3	+	+	+	+	+		+	+	+	+	+	+	+	+	+	+	+
FOCUS	+						+	+		+	+			+
MRFIT	+	+	+	+			+	+	+	+	+	+	+	+	+		+
ALLHAT	+	+	+	+			+	+	+	+	+	+	+	+
BHS			+	+			+		+				+		+
CORAL	+		+	+		+	+		+	+	+	+	+	+			+
NGHS			+										+				+
OMNI heart			+	+									+
POWER-UP	+		+		+		+	+	+	+	+	+	+	+			+
SPRINT-POP	+		+	+			+		+	+	+			+			+

Ageing diseases=dementia, Alzheimer’s or Parkinson’s.

*All events include both fatal and non-fatal.

†Based on serum potassium and creatinine levels, and need for dialysis.

‡Based on amputations.

§Only 1973–1975.

ACCORD, Action to Control Cardiovascular Risk in Diabetes; AFFIRM, Atrial Fibrillation Follow-Up Investigation of Rhythm Management; ALLHAT, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial; ARIC, Atherosclerosis Risk in Communities; BARI 2D, Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes; BHS, Bogalusa Heart Study; CABG, coronary artery bypass grafting; CAD, coronary artery disease; CHF, congestive heart failure; CORAL, Cardiovascular Outcomes in Renal Atherosclerotic Lesions; CVD, cardiovascular disease; FHS, Framingham Heart Study; FOCUS, Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair; JHS, Jackson Heart Study; MI, myocardial infarction; MRFIT, Multiple Risk Factor Intervention Trial for the Prevention of Coronary Heart Disease; NGHS, NHLBI Growth and Health Study; OMNI heart, Optimal Macronutrient Intake Trial to Prevent Heart Disease; PCI, percutaneous coronary intervention; POWER-UP, Practice Based Opportunities for Weight Reduction Trial at the University of Pennsylvania; SPRINT-POP, Systolic Blood Pressure Intervention Trial Primary Outcome Paper; TIA, transient ischaemic attack; T2DM, type 2 diabetes mellitus.