Table 3.

Specificity and positive predictive value (PPV) of the short high-dose cosyntropin test for the diagnosis of adrenal insufficiency (AI), according to serum cortisol cut-off concentrations (classic and sex-specific and assay-specific), and as a function of the suspected origin of the disease

	Classic cut-off values						Sex-specific and assay-specific cut-off values
	Global		Clinical suspicion				Global		Clinical suspicion
			Primary AI		Central AI				Primary AI		Central AI
Sampling time (min)	30	60	30	60	30	60	30	60	30	60	30	60
Specificity (%)	86	99	95	100	79	98	89	98	96	100	84	97
PPV (%)	68	97	74	100	66	96	65	93	75	100	61	90