Table 1.
Demographic and Medical Variables for Entire Sample, Infants Without/With Respiratory Distress Syndrome (RDS), and Infants Without/With Chronic Lung Disease (CLD).
| Variable | Sample | Without RDS | With RDS | Without CLD | With CLD |
|---|---|---|---|---|---|
| N = 31 | n = 3 | n = 28 | n = 18a | n = 12a | |
| Gender, female | 11 (35.5) | 1 (33.3) | 10 (35.7) | 8 (44.4) | 3 (25) |
| Race | |||||
| Caucasian | 26 (83.8) | 2 (66.7) | 24 (85.7) | 15 (83.3) | 10 (83.4) |
| African American | 3 (9.7) | 0 (0) | 3 (10.7) | 2 (11.1) | 1 (8.3) |
| Other | 2 (6.5) | 1 (33.3) | 1 (3.6) | 1 (5.6) | 1 (8.3) |
| Premature rupture of membranes | |||||
| No/unknown | 19 (61.3) | 1 (33.3) | 18 (64.3) | 12 (66.7) | 6 (50) |
| Yes | 12 (38.7) | 2 (66.7) | 10 (35.7) | 6 (33.3) | 6 (50) |
| Antenatal steroids‡ | |||||
| No/unknown | 1 (3.2) | 0 (0) | 1 (3.6) | 0 (0) | 1 (8.3) |
| Yes | 30 (96.8) | 3 (100) | 27 (96.4) | 18 (100) | 11 (91.7) |
| Gestational age at birth (weeks) | 29.0 ± 1.9 | 29.4 ± 4.0 | 29.0 ± 1.7 | 29.5 ± 1.9 | 28.2 ± 1.6* |
| Birth weight (g) | 1,192 ± 376 | 1,569 ± 863 | 1,152 ± 290 | 1,323 ± 397 | 1,022 ± 271* |
| Apgar score | |||||
| 1 min | 4.7 ± 2.3 | 6.7 ± 3.2 | 4.4 ± 2.2 | 5.0 ± 2.4 | 3.8 ± 2.0 |
| 5 min | 6.9 ± 1.4 | 7.7 ± 1.5 | 6.8 ± 1.4 | 6.8 ± 1.4 | 6.8 ± 1.5 |
| First pHb | 7.31 ± 0.07 | 7.29 ± 0.1 | 7.31 ± 0.1 | 7.31 ± 0.1 | 7.30 ± 0.1 |
| No. of days of ventilator support by Day 7 | 3.0 ± 3.0 | 2.7 ± 4.6 | 3.0 ± 2.9 | 1.6 ± 1.9 | 5.2 ± 3.2** |
| Length of stay (days) | 83.5 ± 28.7 | 83.0 ± 36.0 | 83.5 ± 28.6 | 73.9 ± 23.4 | 97.8 ± 30.9* |
| Surfactant | |||||
| No | 13 (41.9) | 2 (66.7) | 11 (39.3) | 8 (44.4) | 4 (33.3) |
| Yes | 18 (58.1) | 1 (33.3) | 17 (60.7) | 10 (55.6) | 8 (66.7) |
| FIO2 c | |||||
| Admission | 0.32 ± 0.13 | 0.23 ± 0.03 | 0.33 ± 0.13 | 0.32 ± 0.12 | 0.34 ± 0.15 |
| 12 hr | 0.26 ± 0.09 | 0.21 ± 0.01 | 0.27 ± 0.09 | 0.24 ± 0.03 | 0.30 ± 0.13* |
| Day 7 | 0.25 ± 0.06 | 0.21 ± 0.01 | 0.25 ± 0.06 | 0.23 ± 0.04 | 0.28 ± 0.07** |
Note. Values are provided as mean ± SD or n (%). Mann–Whitney U and Fisher’s exact tests were used for comparison between infants without/with RDS and infants without/with CLD. Pairwise deletions were used for missing data.
aTotal infants without/with CLD are 30 because of an infant passing prior to the diagnosis of CLD, which occurs at 36 weeks’ gestation. bFirst recorded pH in medical record from venous, capillary, and arterial samples. cThe average fraction of inspired oxygen (FIO2) recorded in the first hour after admission to the neonatal intensive care unit, the average FIO2 recorded during the first 12 hr after birth (Hr 1–12), and the average FIO2 recorded on Day 7 (24-hr average).
*p < .05 and **p < .01 between infants without/with CLD.