Table 3.
Symptoms Associated With Genotype in Preeclampsia.
| Symptom | Gene SNP | Genotype | With Symptom | Without Symptom | p Value |
|---|---|---|---|---|---|
| N (%) | N (%) | ||||
| Headaches | CFH rs1329428 | C/C C/T T/T | 30 (27.3) 24 (21.8) 11 (10.0) | 10 (9.1) 28 (25.5) 7 (6.4) | .02 |
| CFH rs1329428 | C/C vs. C/T + T/T | 30 (27.3) 35 (31.8) | 10 (9.1) 35 (31.8) | .02 | |
| Visual disturbances | CFH rs1329428 | C/C C/T T/T | 20 (18.2) 14 (12.7) 7 (6.4) | 19 (17.3) 39 (35.5) 11 (10.0) | .05 |
| CFH rs1329428 | C/C vs. C/T + T/T | 20 (18.2) 21 (19.1) | 19 (17.3) 50 (45.5) | .04 | |
| S100A8 rs3795391 | C/C C/T T/T | 0 (0.0) 1 (0.9) 39 (36.8) | 1 (0.9) 17 (16.0) 48 (45.3) | .002 | |
| S100A8 rs3795391 | C/C + C/T vs. T/T | 1 (0.9) 39 (36.8) | 18 (17.0) 48 (45.3) | .001 | |
| F11R rs7546890 | C/C vs. C/T + T/T | 15 (13.8) 25 (22.9) | 12 (11.0) 57 (52.3) | .02 | |
| Fatigue/tiredness | S100A8 rs3795391 | C/C C/T T/T | 1 (0.9) 10 (9.3) 73 (68.2) | 0 (0.0) 8 (7.5) 15 (14.0) | .03 |
| S100A8 rs3795391 | C/C + C/T vs. T/T | 11 (10.3) 73 (68.2) | 8 (7.5) 15 (14.0) | .03 | |
| Other | S100A8 rs3795391 | C/C + C/T vs. T/T | 2 (1.9) 30 (29.1) | 16 (15.5) 55 (53.4) | .05 |
| Nausea and/or vomiting | S100A8 rs3795391 | C/C C/T T/T | 1 (0.9) 7 (6.5) 59 (55.1) | 0 (0.0) 11 (10.3) 29 (27.1) | .03 |
| FSTL3 rs1046253 | A/A G/A G/G | 1 (0.9) 30 (27.8) 36 (33.3) | 4 (3.7) 9 (8.3) 28 (25.9) | .02 | |
| Indigestion/heartburn | F11R rs11265544 | A/A A/C C/C | 22 (20.6) 32 (29.9) 15 (14.0) | 19 (17.8) 17 (15.9) 2 (1.9) | .04 |
| F11R rs11265544 | A/A + A/C vs. C/C | 54 (50.5) 15 (14.0) | 36 (33.6) 2 (1.9) | .03 | |
| Palpitations | F11R rs836 | A/A G/A G/G | 3 (2.8) 1 (0.9) 9 (8.4) | 6 (5.6) 43 (40.2) 45 (42.1) | .006 |
| Shortness of breath | F11R rs836 | A/A + A/G vs. G/G | 24 (22.0) 15 (13.8) | 29 (26.6) 41 (37.6) | .05 |
| Back pain | CFH rs10922096 | C/T + T/T vs. C/C | 28 (25.7) 18 (16.5) | 50 (45.9) 13 (11.9) | .05 |
Note. SNP = single-nucleotide polymorphism.