Skip to main content
. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Nat Chem. 2017 Nov 6;10(2):165–169. doi: 10.1038/nchem.2871

Figure 1. Methods for amine α-C–H bond functionalization and new concept for secondary amines.

Figure 1

This Figure summarizes some of the most widely used methods for amine α-C–H bond functionalization: a, Deprotonative/cross-coupling approach. b, Directing group-based approach involving oxidative C–H insertion by a metal catalyst. c, Oxidative approach (Cross-dehydrogenative coupling). d, Photoredox-based method. e, Hydroaminoalkylation. f, Redox-neutral condensation. g, This work: Intermolecular hydride transfer based approach.