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. 2016 Feb 10;10(4):214–223. doi: 10.1177/1753944716630653

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Figure 5. — Transmission electron microscopic study of ventricle tissue of rat heart. Group I: normal control group showing normal architecture of the heart mitochondria. Groups II and III: per se groups treated with benidipine + edaravone (1 μg/kg + 1 mg/kg and 3 μg/kg + 3 mg/kg) dose showing normal mitochondria along with good appearance of myofilaments of the heart mitochondria. Group IV: toxic group treated with isoproterenol (ISO; 85 mg/kg, subcutaneous) heart mitochondria showing ruptured mitochondrial cell membrane, bulging of mitochondria and disorder of cristae with vacuolation. Group V: group treated with benidipine + edaravone (1 μg/kg + 1 mg/kg) + ISO showing disarrangement of cristae with some swelling and vacuolation. Group VI: pretreated group, treated with benidipine + edaravone (3 μg/kg + 3 mg/kg) + ISO showing heart mitochondria with maintained architecture and slight fibrosis of mitochondria space. Scale bar = 50 μm.