Table 2.
Baseline characteristics independently associated with major bleeding in ARISTOTLE [Hylek et al. 2014].
| Parameter | HR | 95% CI | p |
|---|---|---|---|
| Hematocrit < 45% | 1.38 | (1.24–1.52) | <0.001 |
| History of bleeding | 1.38 | (1.17–1.63) | 0.002 |
| Age (per 10 years) | 1.36 | (1.23–1.51) | <0.001 |
| NSAIDs at randomization | 1.33 | (1.07–1.65) | 0.0096 |
| Aspirin at randomization | 1.31 | (1.14–1.52) | 0.002 |
| Diabetes | 1.24 | (1.06–1.45) | 0.0067 |
| Prior stroke | 1.23 | (1.04–1.45) | 0.016 |
| Creatinine clearance (<81 ml/min/1.73 m2) | 1.11 | (1.06–1.17) | <0.001 |
| Female sex | 0.74 | (0.63–0.87) | 0.002 |
| Liver disease | 0.44 | (0.22–0.88) | 0.02 |
CI, confidence interval; HR, hazard ratio; NSAIDs, nonsteroidal anti-inflammatory drugs.