Table 2. Virulence factors that were more frequently detected in one lineage than the other (lineages I and II).
| Gene/Locus | Annotation | % Present in Lineage I Isolates (% Present in CC) | % Present in Lineage II Isolates (% Present in CC) | P-Value |
|---|---|---|---|---|
| lmo0320 (a) | Peptidoglycan bound surface protein (b) | 100 (100) (c) | 39 (61) (c) | < 0.001 (d) |
| lmo0478 | Secreted protein | 19 (20) | 94 (89) | < 0.0001 |
| lmo1076 | Autolysin (aut) | 60 (60) | 98 (96) | < 0.01 |
| lmo1081 to lmo1082 | Glucose-1-phosphate thymidyl transferase / dTDP-sugar epismerase | 60 (60) | 98 (96) | < 0.01 |
| lmo2026 | Peptidoglycan binding protein | 0 (0) | 58 (39) | < 0.001 |
| lmo2177 | Hypothetical protein | 0 (0) | 100 (100) | < 0.0001 |
| LMOf2365_0693 | Cell wall surface anchor family protein | 100 (100) | 0 (0) | < 0.0001 |
| LMOf2365_0032, LMOf2365_0036 to LMOf2365_0037 | Arginine/Ornithine antiporter | 100 (100) | 26 (32) | < 0.0001 |
| LMOf2365_2627 | ABC Transporter | 32 (32) | 0 (0) | < 0.01 |
| Lm4b_00073 | Hypothetical protein | 24 (24) | 60 (50) | < 0.05 |
| lmo0463 | Peptidoglycan bound protein (LPXTG motif) | 98 (96) | 51 (54) | < 0.001 |
| LMOATCC19117_0357 to LMOATCC19117_0360 | Epismerase/dehydrogatase family protein and transcriptional regulator | 41 (40) | 0 (0) | < 0.001 |
| LIPI-3 | Listeria Pathogenicity Island 3 | 72 (68) | 1 (3) | < 0.0001 |
| LIPI-4 | Listeria Pathogenicity Island 4 | 32 (28) | 0 (0) | < 0.01 |
(a) Virulence factor loci
(b) Virulence factor annotations
(c) Frequency of detection in isolates (and CCs).
(d) Fisher’s exact test P-value. A P-value < 0.5 indicates a significant difference in the detection frequency of that virulence factor between lineages I and II.