Table 1. Pharmacokinetic parameters calculated.

	Definition	Determination
AUC(0→t) (ng·h/mL)	Area Under the Curve from 0 to the time of the last quantifiable concentration	Trapezoidal rule
AUC(inf) (ng·h/mL)	Area Under the Curve from 0 to infinity	${AUC}_{\left(inf\right)}={AUC}_{(0\to t)}+\frac{C_t}{{\lambda }_z}$
AUMC(last) (ng·h2/mL)	Area under the first moment curve to the time of the last quantifiable concentration	Trapezoidal rule
AUMC(inf) (ng·h2/mL)	Area Under the first Moment Curve from time 0 to infinity	${AUMC}_{\left(inf\right)}={AUMC}_{\left(last\right)}+\frac{C_t*t_{last}}{{\lambda }_z}+\frac{C_t}{{{\lambda }_z}^2}$
C0 (ng/mL)	Initial (or fictive) concentration at time zero for bolus iv adm
Cl (L/h/kg)	Total body clearance (iv adm) (after i.v. adm, F = 1)	$Cl=\frac{F*D}{{AUC}_{\left(inf\right)}}$
λz	Apparent first order terminal elimination rate constant	Estimated terminal slope of the linear regression of log-transformed concentration vs. time curve
MRT (0→∞) (h)	Mean Residence Time	$MRT=\frac{{AUMC}_{\left(inf\right)}}{{AUC}_{\left(inf\right)}}$
t1/2 (min)	Terminal elimination half-life or apparent terminal elimination half-life	$t_{1/2}=\frac{Ln2}{{\lambda }_z}$
Vz (L/kg)	Volume of distribution at terminal phase (iv adm)	$V_z=\frac{Cl}{{\lambda }_z}$

AUC: area under the curve; AUMC: Area Under the first Moment Curve; C₀: extrapolated concentration at time = 0 min; D: Dose; Cl: clearance; F: bioavailability; λ_z: Apparent first order terminal elimination rate constant; MRT: mean residence time; t_1/2: half-life; Vz: volume of distribution.