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. 2018 May 9;13(5):e0197061. doi: 10.1371/journal.pone.0197061

Table 2. Pharmacokinetic parameters after single intravenous bolus administration of SNF472 into rats.

1 mg/kg 5 mg/kg 10 mg/kg
C0 (ng/mL) 36775 84561 156750
t1/2 (min) 1.8 6.6 7.8
AUC(0→t) (ng·h/mL) 3491 19234 38752
MRT (0→∞) (h) 1.65 0.33 0.19
Vz (L/kg) 0.01 0.04 0.05
Cl (L/h/kg) 0.29 0.26 0.26

C0: extrapolated concentration at time = 0 min; t1/2: half-life; AUC: area under the curve; MRT: mean residence time; Vz: volume of distribution; Cl: clearance