Skip to main content
. 2018 May 9;13(5):e0197061. doi: 10.1371/journal.pone.0197061

Table 3. Pharmacokinetic parameters after single subcutaneous bolus administration of SNF472 into rats.

10 mg/kg 30 mg/kg 100 mg/kg
Cmax (ng/mL) 4876 61014 263264
t1/2 (min) 3.9 17.0 11.5
AUC(0→t) (ng·h/mL) 1633 32646 139603
MRT (0→∞) (h) 0.47 0.48 0.49
Vz/F (L/kg) 0.48 0.48 0.61
Cl/F (L/h/kg) 0.22 0.27 0.21

Cmax: maximum concentration measured; t1/2: half-life; AUC: area under the curve; MRT: mean residence time; Vz: volume of distribution; Cl: clearance; F: absolute bioavailability