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. 2018 May 9;13(5):e0197322. doi: 10.1371/journal.pone.0197322

Fig 7. Photopic ERG responses in saline-treated and TIMP1-treated rd1 retinas.

Fig 7

Confocal micrographs of whole-mounts immunohistological stained for M-opsin in P90 saline-treated and P90 TIMP1-treated retinas (A). In the TIMP1-treated retina, M-opsin immunoreactivity was visible in the cell membrane and outer segments that are shortened and distorted (arrowheads). Photopic ERG recordings from saline-treated rd1 and TIMP1-treated rd1 retinas were shown (B). In addition, an example of waveforms of the photopic ERG responses from P60 normal, P60 saline-treated, and P60 TIMP1–treated retinas were generated (C). The inset shows higher magnification of b-wave (arrow) of both saline-treated and TIMP1-treated P60 retinas. Data represents mean ± SEM; **** P<0.0001, *P<0.05; scale bar = 10 μm; P, postnatal.