Fig 3. CD39 and CD73 expression on CD4⁺ and CD8⁺ T cells from the synovial fluid of inflamed joints.

T cells from the peripheral blood and synovial fluid of JIA patients were analyzed for the expression of HLA-DR, CD39 and CD73. T_reg cells were excluded from analysis (see Fig 2A for gating strategy). (A, B) Representative expression profiles for CD39, CD73 and HLA-DR on conventional CD4⁺ T cells (A) and CD8⁺ T cells (B) from peripheral blood (PB) and synovial fluid (SF). (C) Percentages of HLA-DR⁺ cells among CD4⁺ and CD8⁺ T cells in PB and SF. (D) Percentages of CD39⁺ cells (top) and of CD73⁺ cells (bottom) among HLA-DR⁺ and HLA-DR^—subsets of CD4⁺ and CD8⁺ T cells in peripheral PB and SF. Results for blood and SF of 6 JIA patients are shown. Paired t test, * p<0.05, ** p<0.01, *** p<0.001, ns p>0.05.