Table 2. Number of positive goats to each IFN-γ release assay.
Antigen | Group | Week | |||||||
0 | 3 | 5 | 8 | ||||||
C | S | C | S | C | S | C | S | ||
PPD-Bb | Control | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 |
BCG | 0/8 | 0/8 | 2/8 | 5/8 | 4/8 | 6/8 | 1/8 | 5/8 | |
HIMB | 0/8 | 0/8 | 1/8 | 2/8 | 4/8 | 4/8 | 3/8 | 3/8 | |
ECc | Control | 0/8 | 0/8 | 0/8 | 0/8 | ||||
BCG | 0/8 | 0/8 | 0/8 | 0/8 | |||||
HIMB | 0/8 | 0/8 | 0/8 | 0/8 | |||||
Week | |||||||||
11 | 13 | 15 | 17a | ||||||
C | S | C | S | C | S | C | S | ||
PPD-Bb | Control | 8/8 | 8/8 | 8/8 | 8/8 | 8/8 | 8/8 | 5/7 | 6/7 |
BCG | 8/8 | 8/8 | 8/8 | 8/8 | 8/8 | 8/8 | 8/8 | 8/8 | |
HIMB | 6/7 | 6/7 | 7/7 | 7/7 | 6/7 | 7/7 | 7/7 | 7/7 | |
ECc | Control | 8/8 | 8/8 | 8/8 | 8/7 | ||||
BCG | 8/8 | 8/8 | 8/8 | 8/8 | |||||
HIMB | 7/7 | 7/7 | 6/7 | 7/7 |
Animals were vaccinated at week 0 and challenged at week 8.
a One goat of the Control group was euthanized at week 16.
b PPD-B, M. bovis purified protein derivative; two criteria were used for positivity: C, Conservative (S/P ≥ 35%), and S, Stringent (S/P ≥ 16%).
c EC, ESAT-6/CFP-10 protein mixture; the criterion for positivity was S/P ≥ 16%.