Table 2. Efficacy measures (i.e. cure rates (CRs) and egg reduction rates (ERRs)) by treatment arm against each soil-transmitted helminth species.
| Study | Efficacy parameter | T. trichiura | A. lumbricoides | Hookworm | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | IVM + ALB (95% CI) | ALB alone (95% CI) | IVM alone (95% CI) | N | IVM + ALB (95% CI) | ALB alone (95% CI) | IVM alone (95% CI) | N | IVM + ALB (95% CI) | ALB alone (95% CI) | IVM alone (95% CI) | ||
| Belizario et al., 2003 | CR | 452 | 65% | 32% | 35% | 306 | 78% | 70% | 78% | - | - | - | - |
| ERR | 100% | 97% | 98% | 100% | 100% | 100% | |||||||
| Ismail et al., 1999 | CR | 108 | 81% | 44% | - | - | - | - | - | - | - | - | - |
| ERR | 95% | 70% | |||||||||||
| Knopp et al., 2010 | CR | 303 | 38% (29.8–46.4) |
10% (5.4–16.3) |
- | 34 | 93% | 100% | - | 81 | 67% | 59% | - |
| ERR | 91% (87.2–94.0) |
40% (21.5–55.7) |
100% | 100% | 96% | 94% | |||||||
| Speich et al., 2015* | CR | 110 | 28% (19.0–36.0) |
- | - | 50 | 98% (94.0–100) |
- | - | 43 | 50% (34.2–65.8) |
- | - |
| ERR | 95% (91.7–96.3) |
100% (99.9–100) |
96% (90.8–98.3) |
||||||||||
Note: IVM + ALB = co-administration of ivermectin-albendazole, ALB = albendazole, IVM = ivermectin. Not all studies provided 95% confidence intervals (CIs).
*Speich et al. 2015 [24] compared ivermectin-albendazole to albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole alone.