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. 2018 May 9;4(5):eaas9274. doi: 10.1126/sciadv.aas9274

Fig. 4. Evidence of the gap junction–mediated bystander killing effect in the 661W cells.

Fig. 4

(A) Representative bright field (BF) and fluorescence images show apoptosis distribution, detected by SYTOX staining, in different gap junction inhibitors (octanol, 1 mM; quinine, 50 μM; meclofenamic, 100 μM) after 6 hours of blue light irradiation on the 661W-containing NN-Chip. White circles represent the initial irradiated area. Scale bar, 1 mm. (B) Schematic of the 405-μm laser spot diameter irradiation of the NN-Chip. Apoptosis was counted every hour for 24 hours after blue light irradiation (n = 10).