Table 3.

Receiver operating characteristics (ROC) and net reclassification analyses

	Endpoint	AUC (%) with 95% CI without hs-cTnI	AUC (%) with 95% CI with hs-cTnI	P-value for difference	The continuous NRI with 95% CI
Men	All-cause death	73.2 (70.5,75.8)	74.2 (71.5,76.8)	0.0014	0.24 (0.14,0.35)
	Incidence of CVD	63.5 (59.6,67.3)	65.9 (62.1,69.7)	0.0049	0.27 (0.08,0.40)
	Incidence of CHD	62.7 (58.5,66.9)	65.0 (60.8,69.1)	0.010	0.26 (0.05,0.40)
Women	All-cause death	73.5 (70.9,76.1)	74.4 (71.8,77.0)	0.0064	0.24 (0.11,0.36)
	Incidence of CVD	68.7 (65.6,71.8)	69.6 (66.5,72.7)	0.072	0.20 (0.02,0.29)
	Incidence of CHD	68.5 (65.0,72.0)	69.7 (66.2,73.2)	0.087	0.24 (0.05,0.34)
All	All-cause death	73.9 (72.1,75.8)	74.8 (73.0,76.6)	<0.0001	0.26 (0.18,0.33)
	Incidence of CVD	67.6 (65.2,69.9)	69.0 (66.6,71.3)	0.0007	0.21 (0.11,0.29)
	Incidence of CHD	67.1 (64.5,69.7)	68.8 (66.3,71.4)	0.0010	0.23 (0.12,0.32)

ROC analyses included the following variables: age, diabetes, BMI, hypertension medication, systolic blood pressure, smoking, log CRP, log creatinine, cholesterol, HDL cholesterol, log triglycerides and statin medication. Hs-cTnI = high-sensitive cardiac troponin I; CI: confidence interval; NRI: net reclassification improvement; CVD = Cardiovascular disease; CHD = Coronary heart disease