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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Vet Comp Oncol. 2017 Dec 13;16(2):253–261. doi: 10.1111/vco.12375

Figure 3. Resveratrol (Resv) activates p38 MAPK (A and B), but does not affect AMPK (C and D) or ERK1/2 (E and F) pathways.

Figure 3

Canine HSA cells were incubated with increasing concentrations of resveratrol (20, 50, and 100 μM) for 24 h. p38 MAPK activation was assessed by measuring the phospho p38 MAPK/total p38 MAPK in Frog (A) or DD-1 (B). AMPK activation was assessed by measuring the phospho-AMPK/total AMPK in Frog (C) or DD-1 (D) cells. Likewise, ERK1/2 activation was assessed by measuring the phospho-ERK1/2/total ERK1/2 in Frog (E) or DD-1 (F) cells. Results are shown as Mean +/− SEM (n = 6) from three independent experiments (duplicate of wells on three independent times). * p < 0.05 as compared to control values by one-way ANOVA.