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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Curr Opin Immunol. 2018 Feb 3;51:24–31. doi: 10.1016/j.coi.2018.01.001

Figure 1. Distinct effects of autoreactive antigen receptors in fetal and adult lymphopoiesis.

Figure 1

Fetal and neonatal lymphocytes expressing autoreactive antigen receptors seem to tolerate strong signaling, which may promote their efficient diversion to innate-like T or B cell lineages [36]. In contrast, adult autoreactive lymphocytes are efficiently eliminated by tolerance mechanisms such as negative selection, receptor editing or anergy induction.