Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Curr Opin Immunol. 2018 Feb 3;51:24–31. doi: 10.1016/j.coi.2018.01.001

Figure 3. Clonal evolution of the BCR repertoire of B-1a cells throughout adult life.

Figure 3

The schematic diagrams of the B-1a BCR repertoire in neonatal, young and adult mice are based on data obtained by high-throughput CDR3 sequencing of rearranged Igh transcripts [9]. Each rectangle represents a unique CDR3 sequence, and the size denotes the relative frequency (clone size) of an individual sequence. B-1a cell clones derived from FL HSCs are shown as filled colored rectangles, while B-1a cell clones originating from BM HSC are indicated by white rectangles.